the Lu Lab

We use cutting-edge technology and rigorous experimental design to uncover the secret of neuron-glia interactions.

Lab Research Interests

Current Research focus #1

Oligodendrocyte lineage cell homeostasis across the lifespan

From our birth to death, oligodendrocytes are continuously made from their precursor cells (called OPCs) to accelerate the information processing in our brain. However, why, when, and how OPCs decide to become oligodendrocytes are not clear.

Current Research focus #2

Oligodendrocyte lineage cell homeostasis in Alzheimer’s disease

Oligodendrocyte degeneration is one of the pathological features observed in the brains of Alzheimer’s disease patients, and yet it has been overlooked for over 100 years.

Current Research focus #3

Oligodendrocyte precursor cell reactivity during brain injury

We have known for decades that oligodendrocyte precursor cells (OPCs) are highly responsive to brain trauma — It is also almost the only thing that we know about OPCs during brain injury. How they respond and their roles during trauma remain a mystery.

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